7-oxabicycloheptane substituted thio prostaglandin analogs

Details 7-oxabicycloheptane substituted thio prostaglandin analogs 7-oxabicycloheptane substituted thio prostaglandin analogs

C - Chemistry, Metallurgy

07

D

167/205, 167/245

C07D 493/08 (2006.01) A61K 31/34 (2006.01) A61K 31/557 (2006.01)

Patent

CA 1257286

ABSTRACT 7-OXABICYCLOHEPTANE SUBSTITUTED THIO PROSTAGLANDIN ANALOGS 7-Oxabicycloheptane substituted thio prostaglandin analogs axe provided having the stxuctural formula Image wherein R is hydrogen, lower alkyl or alkali metal, R1 is lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl, X is O, S or NH, A is -CH=CH- or -(CH2)2, p is 0 to 4, n is 1 to 4, n' is 0 to 2, q is 1 to 4 and m is 0 to 8, and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease; and are antiinflammatory agents useful, for example, in the treatment of rheumatoid arthritis.

482871

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