7-oxabicycloheptyl substituted heterocyclic amide...

Details 7-oxabicycloheptyl substituted heterocyclic amide... 7-oxabicycloheptyl substituted heterocyclic amide...

C - Chemistry, Metallurgy

07

D

167/208, 260/302

C07D 493/08 (2006.01) A61K 31/41 (2006.01) A61K 31/557 (2006.01) C07C 45/29 (2006.01)

Patent

CA 2006355

HA481a ABSTRACT 7-OXABICYCLOHEPTYL SUBSTITUTED HETEROCYCLIC AMIDE PROSTAGLANDIN ANALOGS USEFUL IN THE TREATMENT OF THROMBOTIC AND VASOSPASTIC DISEASE 7-Oxabicycloheptane substituted prostaglandin analogs which are thromboxane A2 (TxA2) receptor antagonists or combined thromboxane A2 receptor antagonists/thromboxane synthase inhibitors useful, for example, in treating thrombotic and vasospastic disease have the structural formula Image wherein m is 1, 2 or 3; n is 0, 1, 2, 3 or 4; Z is -(CH2)2- or -CH=CH-, with the proviso when Z is -CH=CH-, n is 1, 2, 3 or 4; R is CO2H, CO2lower alkyl, CH2OH, CO2alkali metal, CONHSOR3, CONHR3a or -CH2-5-tetrazolyl, X is O, S or NH; and where R1, R2, R3 and R3a are as defined herein.

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