7-oxabicycloheptyl substituted heterocyclic amide...

Details 7-oxabicycloheptyl substituted heterocyclic amide... 7-oxabicycloheptyl substituted heterocyclic amide...

C - Chemistry, Metallurgy

07

D

C07D 493/08 (2006.01) A61K 31/41 (2006.01) A61K 31/675 (2006.01) C07F 9/6558 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2070895

HA579 Abstract 7-OXABICYCLOHEPTYL SUBSTITUTED HETEROCYCLIC AMIDE PROSTAGLANDIN ANALOGS USEFUL IN THE TREATMENT OF THROMBOTIC AND VASOSPASTIC DISEASE 7-Oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs are provided which are thromboxane A2 (TXA2) receptor antagonists or combined thromboxane A2 receptor antagonist/throm- boxane synthetase inhibitors and have the structural formula Image wherein R is SO3H, P(O)OR3OH or P(O)R4OH, X is O or NH, and Z, R1, R2, R3 and R4 are as defined herein.

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