7-phenylpyrazolopyridine compounds

Details 7-phenylpyrazolopyridine compounds 7-phenylpyrazolopyridine compounds

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4545 (2006.01) A61K 31/5377 (2006.01) A61K 31/695 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 1/08 (2006.01) A61P 1/10 (2006.01) A61P 1/12 (2006.01) A61P 5/38 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07F 5/02 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2494574

A compound represented by the formula: (see figure I) [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4--tetrahydropyranyl) methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.

L'invention concerne un composé représenté par la formule générale (I), son sel ou des hydrates correspondants. Dans cette formule, R?1¿ représente méthoxy, méthylthio, éthyle, etc., R?5¿ et R?6¿ représentent chacun indépendamment cyclopropylméthyle, (4-tétrahydropyranyl)méthyle, etc., et deux de R?40¿, R?41¿ et R?42¿ sont alcoxy C¿1-6?, le reste se composant de méthoxyméthyle, etc. Le composé susmentionné présente un excellent antagonisme vis-à-vis d'un récepteur du facteur de libération de la corticotropine.

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