7-piperidinoalkyl-3,4-dihydroquinolone derivative

Details 7-piperidinoalkyl-3,4-dihydroquinolone derivative 7-piperidinoalkyl-3,4-dihydroquinolone derivative

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4709 (2006.01) A61P 1/14 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 15/10 (2006.01) A61P 25/00 (2006.01) A61P 25/02 (2006.01) A61P 25/08 (2006.01) A61P 25/18 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/36 (2006.01) A61P 43/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2739513

To provide a novel compound, a pharmaceutically acceptable salt or a hydrate thereof useful for preventing or treating for depression, anxiety disorders (such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, obsessive-compulsive disorder or social anxiety disorder), attention deficit disorder, mania, manic-depressive illness, schizophrenia, mood disorders, stress, sleep disorders, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, cardiovascular diseases, hypertension, dyslipidemia, myocardial infarction, movement disorder (such as Parkinson's disease, epilepsy, convulsion or tremor), drug abuse, drug addiction or sexual dysfunction, based on a melanin-concentrating hormone receptor (MCH receptor) antagonistic action. SOLUTION A compound, a pharmaceutically acceptable salt or a hydrate thereof represented by the formula (I).

L'invention concerne un nouveau composé, un sel pharmaceutiquement acceptable ou un hydrate associés, utiles pour prévenir ou traiter la dépression, les troubles anxieux (tels que l'anxiété généralisée, les troubles de stress post-traumatique, les troubles de panique, les troubles obsessionnels-compulsifs ou les troubles d'anxiété sociale), les troubles de déficit de l'attention, les manies, les affections maniaco-dépressives, la schizophrénie, les troubles de l'humeur, le stress, les troubles du sommeil, les attaques, les troubles de la mémoire, les troubles cognitifs, la démence, l'amnésie, le délire, l'obésité, les troubles du comportement alimentaire, les troubles de l'appétit, l'hyperphagie, la boulimie, la cibophobie, le diabète, les maladies cardiovasculaires, l'hypertension, la dyslipidémie, l'infarctus du myocarde, les troubles du mouvement (comme la maladie de Parkinson, l'épilepsie, les convulsions ou les tremblements), la surconsommation de médicaments, la toxicomanie ou les dysfonctionnements sexuels, fondés sur l'action antagoniste d'un récepteur hormonal concentrant la mélanine (récepteur MCH). La solution est un composé, un sel pharmaceutiquement acceptable ou un hydrate associés représentés par la formule (I). [formule (I)]

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