7-polyaminoalkyl(oxy)iminomethylcamptothecins bearing...

Details 7-polyaminoalkyl(oxy)iminomethylcamptothecins bearing... 7-polyaminoalkyl(oxy)iminomethylcamptothecins bearing...

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2532193

Compounds are disclosed with the general formula (I) in which the groups are as defined in the description here below and characterized by the presence of polyamine substituents on the imine/oxime residue, such amine groups being in turn protected by suitable protective groups. Said compounds are endowed with potent topoisomerase I inhibiting activity and therefore are useful as medicaments for the treatment of tumours and viral and parasite infections.

La présente invention se rapporte à des composés représentés par la formule générale (I), dans laquelle les groupes sont définis dans la description ci-dessous. Ces composés se caractérisent par la présence de substituants polyamine sur le résidu imine/oxime, ces groupes amine étant à leur tour protégés par des groupes protecteurs adaptés. Ces composés sont dotés d'une puissante activité d'inhibition des topoisomérases I et ils s'avèrent par conséquent utiles en tant que médicaments pour le traitement de tumeurs et d'infections virales et parasitaires.

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