7-substituted-4-aza-steroid derivatives as 5-alpha-...

Details 7-substituted-4-aza-steroid derivatives as 5-alpha-... 7-substituted-4-aza-steroid derivatives as 5-alpha-...

C - Chemistry, Metallurgy

07

J

C07J 73/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2174234

Compounds of formula (I) are inhibitors of 5.alpha.-reductase and are useful alone or in combination with 5.alpha.-reductase 1 and/or 2 inhibitors for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern baldness, and benign prostatic hyperplasia.

Les composés de la formule (I) sont des inhibiteurs de la 5-alpha-réductase et sont utiles seuls ou en combinaison avec des inhibiteurs de la 5-alpha-réductase 1 et/ou 2 dans le traitement de troubles hyperandrogéniques comme l'acné vulgaire, la séborrhée, l'hirsutisme, la calvitie hippocratique et l'hypertrophie de la prostate.

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