7-¬(substituted)amino|-8-¬substituted(carbonyl)-...

C - Chemistry – Metallurgy – 07 – D

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C07D 307/94 (2006.01) A61K 31/33 (2006.01) C07D 405/08 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 1264321

Abstract Substituted phenoxy-, 1-, and 2-naphthalenyloxy-, indenyl-, indolyl-, benzofuranyl-, and benzo[b]thio- furanylcarboxamides of 7,8-(substituted-diamino)-1- oxaspiro[4.5]decanes are useful as analgesic agents. A method of making the compounds, pharmaceutical compositions employing the compounds, and a method of alleviating pain in warm-blooded animals are also disclosed. The compounds have the general formula: Image wherein n, R1, R2, R3, x and Y are as defined in the disclosure and claims.

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