7-substituted aminoacetamido oxadethiacephalosporins

Details 7-substituted aminoacetamido oxadethiacephalosporins 7-substituted aminoacetamido oxadethiacephalosporins

C - Chemistry, Metallurgy

07

D

260/244.2, 260/2

C07D 498/04 (2006.01) C07D 505/00 (2006.01)

Patent

CA 1079278

ABSTRACT Antibacterial 7-substituted aminoacetamido oxadethia- cephalosporins of the formula: Image [wherein R is substituted amino, substituted phenyl, or 5- or 6- membered hetero ring; Ar is aryl; Y is hydrogen or methoxy: Het is 5- or 6-membered aromatic hetero ring; and Z is hydroxy or carboxy protecting group] preparable e.g. by acylation of 7.alpha.-methoxy-7.beta.-amino-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives, are highly active against gram-positive and gram-negative bacteria especially those resistant to other cephalosporins and penicillins.

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