7-substituted camptothecin and camptothecin analogs and...

Details 7-substituted camptothecin and camptothecin analogs and... 7-substituted camptothecin and camptothecin analogs and...

C - Chemistry, Metallurgy

07

D

C07D 491/147 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2530046

Methods of forming camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.

L'invention concerne des procédés de formation de composés de camptothécine qui sont des antitumoraux efficaces. Ces composés inhibent l'enzyme topoisomérase I et peuvent alkyler l'ADN du complexe associé clivable de l'ADN de la topoisomérase I.

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