7-substituted indole mcl-1 inhibitors

Details 7-substituted indole mcl-1 inhibitors 7-substituted indole mcl-1 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01) A61K 31/404 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 413/06 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2682356

Compounds of formula (I) which inhibit the activity of anti-apoptotic McI-I protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated McI-I protein are disclosed.

Cette invention concerne des composés permettant d'inhiber l'activité de la protéine Mcl-1 anti-apoptotique, des compositions contenant ces composés et des méthodes pour traiter des maladies impliquant la protéine Mcl-1 non régulée ou surexprimée.

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