C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/104.3
C07D 499/70 (2006.01) A61K 31/545 (2006.01) C07D 501/20 (2006.01) C07D 501/26 (2006.01) C07D 501/28 (2006.01) C07D 501/32 (2006.01) C07D 501/34 (2006.01) C07D 501/60 (2006.01)
Patent
CA 1133895
Abstract of the Disclosure Novel cephalosporin compounds represented by the formula Image wherein . is an acylamino group Image and R' is for example phenyl or furyl, R'' is H CH3; or R is a substituted unreido group Image and R'' is H or CH3, R''' is e.g., C1-C3 alkyl; or is a cyclic unreido group, e.g., imidazolidine-2-one-1-yl and wherein R1 is phenyl, substituted phenyl, thienyl, or furyl; R2 is hydrogen or C1-C3 alkyl; with the proviso that R2 can only be hydrogen when R'' is hydrogen, and R can be a cyclic unreido group only when R2 is C1-C3 alkyl; are broad spectrum antibiotics exhibiting an expanded spectrum of activity vs. gram-negative microorganisms. These novel compounds are prepared by reacting a 7-(.alpha.-amino-.alpha.arylacetamido)-3-car- bamoyloxymethyl-3-cephem-4-carboxylic acid with an appro- priate ?-position side chain.
271409
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
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