7a-heterocycle-substituted hexahydro-1h-pyrrolizine...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2281800

7a-Substituted hexahydro-1H-pyrrolizine compounds having formula (I), wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

L'invention concerne des composés d'hexahydro-1H-pyrrolizine à substitution en 7a ayant la formule (I), dans laquelle A est un fragment hétérocyclique défini, des compositions pharmaceutiques de ces composés, et l'utilisation desdites compositions pour réguler sélectivement la transmission synaptique chez les mammifères.

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