C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/14 (2006.01) A61K 31/437 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01) C07D 311/00 (2006.01)
Patent
CA 2559310
The invention provides compounds of the formula (1), in which R1 is hydrogen, 1-4C-alkyl, 3-7C-cydoalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4C-alkoxy, 1-4C- alkoxy-1-~4C-alkyl, 1-4C-alkoxycarbonyl, 2-4C-alkenyl, 2-4C-alkynyl, fluoro-l- 4C-alkyl or hydroxy-1-4C~alkyl, R2 is hydrogen, 1-4C-alkyl, 3-7C-cydoalkyl, 3- 7C-cycloalkyl.-1-4C-alkyl, 1-4C-alkoxycarbonyl, hy~droxy-1-4C-alkyl, hydroxy-3- 4-C-alkenyl, hydroxy-3-4C-alkinyl, halogen, 2-4C-alkenyl, 2-4C~alkynyl, fluoro- 1-4C-alkyl, cyanomethyl, hydroxy, 1-4C-alkoxy, amino, mono- or di-1- 4C~alkylamino, 1-4C-alkylcarbonylamino, 1-4C-alkoxycarbonylamino, 1-4C-alkoxy- 1-4C~alkoxycarbonylamino, carboxyl, mono- or di-1-4C-alkylamino-1-4C-alkyl, 1- 4C-alkylcarbonyl, 2~4C-alkenylcarbonyl, 2-4C-alkinylcarbonyl or the radical - CO-NR21R22, R3 is 1-4C-alkylcarbonyl, hydroxy-1-4C-alkyl, 1-4C-alkoxy-1-4C- alkyl, 1-4C-alkoxy-1-4C-alkoxy-l~4C-alkyl, 1-4C-alkoxycarbonyl, fluoro-1-4C- alkoxy-1-4C-alkyl, cyano, the radical -CO-NR31R32, the radical -S02-NR31 R32, the radical -CS-NR31 R32, the radical -C=N(OH)-NR1 R32 or the group Het. Arom is a R4-, R5-, R6- and R7-substituted mono- or bicyclic aromatic radical selected from the group consisting of phenyl, naphthyl, pyrrolyl, pyrazolyl, imidazolyl, 1,2,3-triazolyl, indolyl, benzimida~zolyl, furanyl (furyl), benzofuranyl (benzofuryl), thiophenyl (thienyl), benzothiophenyl (ben~zothienyl), thiazolyl, isoxazolyl, pyridinyl, pyrimidinyi, quinolinyl and isoquinolinyl. The compounds inhibit the secretion of gastric acid.
L'invention concerne des composés représentés par la formule générale (1), les substituants et les symboles de cette formule étant définis dans la description de la présente demande. Ces composés inhibent la sécrétion d'acide gastrique.
Buhr Wilm
Palmer Andreas
Altana Pharma Ag
Gowling Lafleur Henderson Llp
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