7h-benzo¬b|pyrazino¬1,2-d|pyrrolo¬3,2,1-jk|¬1,4|...

Details 7h-benzo¬b|pyrazino¬1,2-d|pyrrolo¬3,2,1-jk|¬1,4|... 7h-benzo¬b|pyrazino¬1,2-d|pyrrolo¬3,2,1-jk|¬1,4|...

C - Chemistry, Metallurgy

07

D

167/210, 260/239

C07D 487/14 (2006.01) A61K 31/55 (2006.01) C07D 487/16 (2006.01)

Patent

CA 2018736

HOE 89/S 008 Abstract 7H-Benzo[b]pyrazino[1,2-d]pyrrolo[3,2,1-jk][1,4]- benzodiazepines, a process for their preparation and their use as medicaments The present invention relates to 7H-benzo[b]pyrazino- [1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines of the formula Image wherein R is hydrogen, loweralkyl, or a group of the formula COO(CR1Z)mCR2R3R4, wherein R1, R2, R3 and R4 are independently hydrogen or loweralkyl, Z is hydrogen, loweralkyl, or halogen, and m is 0 or 1; X and Y are independently hydrogen, halogen, loweralkyl, or trifluoromethyl; the dotted line represents an optional carbon-tocarbon bond; an optical isomer thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for treating depression alone or in combination with inert adjuvants. The invention relates also to a process and intermediates for the preparation of the above compounds.

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