7h-dibenzo[b,g][1,5]dioxocin-5-one derivatives and use thereof

Details 7h-dibenzo[b,g][1,5]dioxocin-5-one derivatives and use thereof 7h-dibenzo[b,g][1,5]dioxocin-5-one derivatives and use thereof

C - Chemistry, Metallurgy

07

D

C07D 321/12 (2006.01) A61K 31/365 (2006.01) A61P 9/00 (2006.01) C07D 405/06 (2006.01) C07D 407/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 491/08 (2006.01) C07F 7/08 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2503881

The invention relates to substituted 7H-dibenzo[b,g][1,5]dioxocin-5-one derivatives, to a method for their production and to the use thereof in medicaments, in particular as inhibitors of the cholesteryl ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular diseases, in particular hypolipoproteinaemia, dyslipidaemia, hypertriglyceridaemia, hyperlipidaemia and arteriosclerosis.

La présente invention concerne des dérivés de 7H-dibenzo[b,g][1,5]dioxocine-5-one substitués, des procédés de production de ces dérivés et leur utilisation dans des médicaments, notamment en tant qu'inhibiteurs de la protéine de transfert des esters de cholestérol (CETP) pour traiter et/ou prévenir des maladies cardio-vasculaires, notamment l'hypolipoprotéinémie, la dyslipidémie, l'hypertriglycéridémie, l'hyperlipidémie et l'artériosclérose.

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