7tm receptor hlwar77

Details 7tm receptor hlwar77 7tm receptor hlwar77

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2233584

HLWAR77 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HLWAR77 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis, angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

Des polypeptides HLWAR77, des polynucléotides correspondants et des méthodes d'obtention de tels polypeptides par des technique d'ADN recombinant sont divulguées. Sont aussi divulguées des méthodes d'utilisation des polypeptides et polynucléotides HLWAR77 dans l'établissement de protocoles de traitement des infections bactériennes, fongiques, à protozoaires, virales, en partiulier les infections dues au VIH-1 ou au VIH-2; de la douleur, des cancers; du diabète, de l'obésité; de l'anorexie; de la boulimie; de l'asthme; de la maladie de Parkinson; de l'insuffisance cardiaque aiguë; de l'hypotension; de l'hypertension; de la rétention urinaire; de l'ostéoporose; de l'angine de poitrine; de l'infarctus du myocarde; des ulcères; de l'asthme; des allergies; de l'hypertrophie prostatique bénigne; et des troubles psychotiques et neurologiques, y compris le trouble anxieux, la schizophrénie, le trouble bipolaire, le délire, la démence, les retards mentaux importants et les dyskinésies, comme la maladie de Huntington ou la maladie de Gilles de La Tourette, entre autres, et dans des tests de diagnostic de ces maladies.

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