8,10-dideazatetrahydrofolic acid derivatives

Details 8,10-dideazatetrahydrofolic acid derivatives 8,10-dideazatetrahydrofolic acid derivatives

C - Chemistry, Metallurgy

07

D

167/219, 260/242

C07D 471/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2016829

ABSTRACT OF THE DISCLOSURE 8,10-Dideazatetrahydrofolic acid derivatives of the formula: Image where R1 and R2 are selected from hydrogen and alkyl having from one to about eight carbon atoms and the carboxylates and acid addition salts thereof, showing strong inhibition of L1210 murine leukemia cells in culture, modest inhibition of glycinamide ribotide transformylase and aminoimidazole carboxamide ribotide transferase, and insignificant inhibition of dihydrofolate reductase and thymidylate synthase enzymes.

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