8-(1h-tetrazol-5-yl)-11h-pyrido¬2,1-b| quinazolin-11-ones

C - Chemistry – Metallurgy – 07 – D

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260/242.01

C07D 471/04 (2006.01) C07D 491/14 (2006.01) C07D 491/147 (2006.01)

Patent

CA 1197844

ABSTRACT OF THE DISCLOSURE The present invention relates to 8-(lH-tetrazol-5- yl)-llH-pyrido[2,l-b]quinazolin-ll-ones having the following structure: Image I wherein R1 and R2 are hydrogen, loweralkyl, halogen, hydroxy, or R1 and R2 are each loweralkoxy of 1 to 3 carbon atoms, with the proviso that when one of R1 or R2 is loweralkoxy the other may not be hydrogen, and R1 and R2 together form methylenedioxy; R3 is carboxamido, cyano or 5-tetrazolyl groupings and the pharmaceutically acceptable salts of acids and bases thereof. These compounds exhibit anti-allergic properties and are useful as anti-asthmatic agents.

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