8-alkoxyquinolonecarboxylic acid salts thereof excellent in...

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C - Chemistry, Metallurgy

07

D

167/211, 260/285

C07D 215/56 (2006.01) A61K 31/47 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01)

Patent

CA 1340316

Quinolonecarboxylic acid derivatives of the following formula, (see fig. I) wherein R indicates a hydrogen atom or lower alkyl group, R1 indicates a lower alkyl group, R2 indicates a hydrogen atom, amino group or nitro group, X indicates a halogen atom, and Z indicates a halogen atom, piperazino group, N-methylpiperazino group, 3-methylpiperazino group, 3-hydroxypyrrolidino group, or pyrrolidino group of the following formula, (see fig. II) (here, n is or 1, R3 indicates a hydrogen atom or lower alkyl group, R4 indicates a hydrogen atom, lower alkyl group or substituted lower alkyl group and R5 indicates a hydrogen atom, lower alkyl group, acyl group or alkoxycarbonyl group), the hydrates and pharmaceutically acceptable salts thereof are useful as anti-bacterial agents.

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