8.alpha.-oestra-1,3,5(10)-triene derivatives, processes for...

Details 8.alpha.-oestra-1,3,5(10)-triene derivatives, processes for... 8.alpha.-oestra-1,3,5(10)-triene derivatives, processes for...

C - Chemistry, Metallurgy

07

J

260/21, 260/45

C07J 1/00 (2006.01) C07J 17/00 (2006.01)

Patent

CA 1170651

NEW 8.alpha.-OESTRA-1,3,5(10)-TRIENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS. ABSTRACT The invention relates to new 8.alpha.-oestra-1,3,5(10)- triene derivatives having the formula: Image in which R1 = H or a free, esterified or etherified hydroxy group; R2 = H or a free, esterified or etherified hydroxy group, with the proviso that at least one of the substituents R1 and R2 is different from H; R3 = alkyl (1-4 C) and R4 = O or (.alpha.X) (.beta.Y), in which X = H or aliphatic hydrocarbyl (1-4 C) and Y = a free, esterified or etherified hydroxy group and the enantiomers and racemic mixtures thereof, and also extends to processes for their preparation and to pharmaceutical compositions containing said new compounds.

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