8-and 9-prostaglandin derivatives, process for their...

Details 8-and 9-prostaglandin derivatives, process for their... 8-and 9-prostaglandin derivatives, process for their...

C - Chemistry, Metallurgy

07

C

260/235.01

C07C 405/00 (2006.01) A61K 31/557 (2006.01)

Patent

CA 2036383

ABSTRACT The invention relates to .DELTA. 8- and .DELTA. 9-prostaglandin derivatives of formula I, Image (I), in which Image means the radicals Image or Image , , R1 means --- Image , Image , COOR4 or CONHR5, R2 and R3 respectively mean a hydrogen atom or a hydroxy group, and the OH group can be respectively in alpha- or beta- position, X means a CH2 group, an O or S atom, W means hydrogen, -OR6, halogen, -CN-, -NO2, trifluoromethyl or COOR6, and, if R4 means hydrogen, their salts with physiologically compatible bases, the alpha-, beta- or gamma- cyclodextrin clathrates, as well as the compounds of formula I encapsulated with liposomes, process for their production and their pharmaceutical use.

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