C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2704125
The invention relates to imidazopyridines of formula I with anti -cancer and/or anti- inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperprolif erative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
L'invention concerne des imidazopyridines de la formule I ayant une activité anticancéreuse et/ou anti-inflammatoire et plus précisément des imidazopyridines qui empêchent une activité de kinase de MEK. L'invention concerne des compositions et des procédés utiles pour inhiber une croissance cellulaire anormale, ou pour traiter un trouble hyper prolifératif ou une maladie inflammatoire chez un mammifère. L'invention concerne également des procédés d'utilisation des composés pour un diagnostic ou un traitement in vitro, in situ et in vivo de cellules de mammifère, ou de conditions pathologiques associées. (Formule I).
Heald Robert
Price Stephen
Savy Pascal Pierre Alexandre
Genentech Inc.
Smart & Biggar
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