8-(anilino)-1-naphthalenesulfonate analogs and their use in...

Details 8-(anilino)-1-naphthalenesulfonate analogs and their use in... 8-(anilino)-1-naphthalenesulfonate analogs and their use in...

C - Chemistry, Metallurgy

09

B

C09B 27/00 (2006.01) C07C 309/47 (2006.01) C12Q 1/28 (2006.01) C12Q 1/54 (2006.01)

Patent

CA 2385923

8-(anilino)-1-naphthalenesulfonate (ANS) analogs and methods for their use in analyte detection assays are provided. The subject ANS analogs are characterized by having at least one non-hydrogen substituent on their phenyl moiety and producing a reaction product with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) or an analog thereof, e.g. MBTHSB, that exhibits reduced drift. In certain preferred embodiments, the subject ANS analogs are described by formula (I) wherein: n is 1 to 5; and X is a substituent other than H. The subject ANS analogs find use in a variety of applications, particularly in analyte detection assays, such as glucose detection assays.

L'invention concerne des analogues de 8-(anilino)-1-naphthalènesulfonate (ANS) ainsi que leurs procédés d'utilisation dans des dosages de détection d'analytes. Ces analogues d'ANS se caractérisent par la présence d'au moins un substituant autre que l'hydrogène sur leur groupe phényle et la production d'un produit de réaction avec le chlorhydrate de 3-méthyl-2-benzothiazolinone hydrazone (MBTH) ou avec un analogue, tel que MBTHSB, qui présente une dérive réduite. Dans certains modes de réalisation préférés, les analogues d'ANS correspondent à la formule (I), dans laquelle n est compris entre 1 et 5, et X est un substituant autre que H. Ces analogues sont utiles dans de nombreuses applications, et notamment dans des dosages de détection d'analytes tels que des dosages de détection du glucose.

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