8-arylalkyl-3-phenyl-3-nortropanols, their acid addition...

Details 8-arylalkyl-3-phenyl-3-nortropanols, their acid addition... 8-arylalkyl-3-phenyl-3-nortropanols, their acid addition...

C - Chemistry, Metallurgy

07

D

260/270.5

C07D 451/06 (2006.01)

Patent

CA 1143734

ABSTRACT The invention relates to 8-arylalkyl-3-phenyl-3-nortropanols of the general formula: Image (wherein Ar represents a group of formula Image R1, Image , or Image Image , in which R1 is hydrogen, fluorine, bromine, methyl or methoxy; X is a Image Image Image Image Image Image F, -O-, -S- or -NH- group; and R is hydrogen, 4-fluorine, 4-chlorine, 4-trifluoromethyl, 3-trifluoromethyl, 3-trifluoromethyl-4-chlorine, 4-methyl or 4-methoxy), and acid addition salts thereof. The compounds I can be obtained by reacting a 3-phenyl-3-nortropanol or the general formula: Image II with an alkylating agent of the general formula Ar-X-CH2-CH2-CH2-y III The compounds exhibit a C.N.S.-sedating action and can be used as neuroleptics.

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