8-arylxanthines

Details 8-arylxanthines 8-arylxanthines

C - Chemistry, Metallurgy

07

D

260/242.4

C07D 473/04 (2006.01) C07D 473/06 (2006.01) C07D 473/08 (2006.01)

Patent

CA 1271473

8-ARYLXANTHINES Abstract of the Disclosure 1,3-alkylsubstituted-8-(3,4-,3- or 4-substituted phe- nyl)xanthines and pharmaceutically acceptable salts of such com- pounds are disclosed. The 3-substituents are hydrogen, dimethylaminomethyl, or 2,3-dihydroxypropyloxy. The 4- substituents are selected from hydroxy, cyano, -NHCON(R5)2, -C(=NH)N(R5)2, -NH-C(=NH)N(R5)2, with each R5 independently being hydrogen or an alkyl group of one to three carbons and provided that when the 3-substituent is hydrogen the 4-substituent is not hydroxy or hydrogen. The compounds are potent adenosine receptor antagonists having relatively low lipophilicity. The compounds are intended for use as bronchodilators and cardiotonics.

551660

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