8-aza-16,16-difluoroprostanoids

Details 8-aza-16,16-difluoroprostanoids 8-aza-16,16-difluoroprostanoids

C - Chemistry, Metallurgy

07

D

260/324, 260/458

C07D 207/26 (2006.01) C07F 9/40 (2006.01)

Patent

CA 1161447

ABSTRACT OF THE DISCLOSURE Biologically active 8-aza-16,16-difluoro- prostanoids having the formula: Image wherein A is CH=CH (cis or trans), C?C, or CH2CH2; R is H, C1-C12 n-alkyl, branched chain alkyl, or cycloalkyl, or a physiologically acceptable metal or amine salt cation; R1 is H, CH3, or C2H5; R2 is CH3, CF3, phenyl, or mono- or di- substituted phenyl, the phenyl sub- stituents being selected from the group F, Cl, CH3, OCH3, NO2, and CF3; n is an integer from 3 to 8 when R2 is CH3 or CF3, or from 0 to 2 when R2 is phenyl or substituted phenyl; as racemic stereo isomer mixtures, or single or mixed optically-active stereo isomers.

383299

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