8-aza-bicyclo (3.2.1) octane derivatives with an activity on...

Details 8-aza-bicyclo (3.2.1) octane derivatives with an activity on... 8-aza-bicyclo (3.2.1) octane derivatives with an activity on...

C - Chemistry, Metallurgy

07

D

C07D 451/04 (2006.01) A61K 31/46 (2006.01) A61P 31/18 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2594602

The present invention provides compounds of formula (I) R3,(I) wherein R1, R2, R3 and R4 are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.

La présente invention concerne des composés ayant la formule (I) dans laquelle R1, R2, R3 et R4 sont définis dans la description. Les composés de la présente invention sont des modulateurs, et plus particulièrement des antagonistes, de l'activité des récepteurs de chimiokines CCR5. Les modulateurs du récepteur de CCR5 peuvent être utiles dans le traitement de divers états et maladies inflammatoires et dans le traitement de l'infection par le VIH et par des rétrovirus qui y sont liés génétiquement.

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