8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives

Details 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives

C - Chemistry, Metallurgy

07

D

C07D 451/02 (2006.01) A61K 31/46 (2006.01) A61K 31/496 (2006.01) A61K 31/498 (2006.01) A61K 31/502 (2006.01) A61K 31/506 (2006.01) A61K 49/00 (2006.01) A61K 49/04 (2006.01) A61K 51/00 (2006.01) A61P 1/00 (2006.01) A61P 1/12 (2006.01) A61P 1/14 (2006.01) A61P 3/04 (2006.01) A61P 5/14 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/06 (2006.01) A61P 15/00 (2006.01) A61P 15/06 (2006.01) A61P 15/10 (2006.01) A61P 17/10 (2006.01) A61P 21/02 (2006.01) A61P 25/00 (2006.01) A61P 25/04

Patent

CA 2342621

The present invention relates to novel 8-azabicyclo[3.2.1]oct-2-ene and - octane derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

La présente invention concerne de nouveaux dérivés de 8-azabicyclo[3.2.1]oct-2-ene et de 8-azabicyclo[3.2.1]octane qui s'avèrent être des ligands cholinergiques aux récepteurs d'acétylcholine nicotiniques. En raison de leur profil pharmacologique, les composés de l'invention peuvent être utiles dans le traitement de maladies ou de troubles aussi divers que ceux liés au système cholinergique du système nerveux central (SNC), de maladies ou de troubles liés à la contraction des muscles lisses, de maladies ou de troubles endocriniens, de maladies ou de troubles liés à la neurodégénération, de maladies ou de troubles liés à l'inflammation, à la douleur, et aux symptômes de sevrage causés par l'arrêt de l'abus de substances chimiques.

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