8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu...

Details 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu... 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu...

C - Chemistry, Metallurgy

07

D

C07D 451/02 (2006.01) A61K 31/46 (2006.01) A61P 1/04 (2006.01) A61P 1/08 (2006.01)

Patent

CA 2695755

The invention provides 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds of formula (I): wherein R2, R7, and m are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.

L'invention concerne des composés de 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide de formule (I), dans laquelle R2, R7 et m sont tels que définis dans la description, ou un sel pharmaceutiquement acceptable de ceux-ci, servant d'antagonistes du récepteur opioïde mu. L'invention concerne également des compositions pharmaceutiques les contenant, des méthodes d'utilisation de ces composés dans le traitement d'affections associées à l'activité du récepteur opioïde mu, ainsi que des procédés et des intermédiaires utiles dans la préparation de ces composés.

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