8.beta.-alkyl-substituted morphinan-6-one compounds

Details 8.beta.-alkyl-substituted morphinan-6-one compounds 8.beta.-alkyl-substituted morphinan-6-one compounds

C - Chemistry, Metallurgy

07

D

260/237.69

C07D 221/28 (2006.01) C07D 471/08 (2006.01) C07D 498/18 (2006.01)

Patent

CA 1093070

Docket No. 11758 8.beta.-ALKYL-SUBSTITUTED MORPHINAN-6-ONE COMPOUNDS ABSTRACT The morphinan-6-one compounds substituted in the 3-position by a methoxy or hydroxy group, in the 8-position by a .beta.-methyl, ethyl or propyl group and in the 17-position by a cyclopropylmethyl or cyclobutylmethyl group are novel and possess analgesic and narcotic antagonist activity. Methods and intermediates useful for preparation of these compounds and therapeutic methods are described.

317750

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