C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/237.65
C07D 489/00 (2006.01) C07D 489/02 (2006.01)
Patent
CA 1106369
8.beta.-ETHYL-AND 8.beta.-METHYL- 4,5.alpha.-EPOXYMORPHINAN 6-ONE COMPOUNDS ABSTRACT Compounds having the structural formula Image in which R1 is a hydrogen atom or methyl group, R2 is an allyl, cyclopropylmethyl, cyclobutylmethyl or tetrahydrofurfuryl group, provided that when R2 is a cyclobutylmethyl or tetrahydrofurfuryl group then R1 is hydrogen, and R3 is an ethyl or methyl group, provided that when R3 is methyl, then R2 is cyclobutylmethyl, and pharmacologically acceptable acid addition salts thereof are novel and possess analgesic and narcotic antagonist activity. Methods for preparation and use of these compounds are described.
320321
Kotick Michael P.
Leland David L.
Polazzi Joseph O.
Schut Robert N.
Miles Laboratories Inc.
Osler Hoskin & Harcourt Llp
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