8-chloro-2,3-benzodiazepine derivatives

Details 8-chloro-2,3-benzodiazepine derivatives 8-chloro-2,3-benzodiazepine derivatives

C - Chemistry, Metallurgy

07

D

C07D 243/02 (2006.01)

Patent

CA 2534458

The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I),wherein R stands for a lower alkyl group or a group of the general formula -NH-R', wherein R' stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives.The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.

L'invention concerne de nouveaux dérivés de 8-chloro-2,3-benzodiazépines de la formule générale (I) (R étant un groupe alkyl inférieur ou un groupe de formule générale -NH-R', R' étant un groupe alkyl inférieur ou un groupe cycloalkyl inférieur), ainsi que des sels d'addition acides pharmaceutiquement acceptables desdits dérivés. L'invention concerne également un procédé de préparation desdits composés, des compositions pharmaceutiques les contenant et de nouveaux intermédiaires servant à la préparation de nouveaux dérivés de 8-chloro-2,3-benzodiazépines. Les composés selon l'invention possèdent une activité d'inhibition du récepteur de AMPA/kainate.

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