8-chloro-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyc...

A - Human Necessities – 61 – K

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Details

A61K 31/445 (2006.01) A61K 9/20 (2006.01) A61K 31/4545 (2006.01) A61K 47/02 (2006.01)

Patent

CA 2325014

Stable pharmaceutical compositions containing 8-chloro- 6,11-dihydro- 11-(4- piperidylidene)- 5H-benzo[5,6] cycloheptic [1,2-b] pyridine ("DCL") and a DCL protective amount of a pharmaceutically acceptable basic salt such as calcium dibasic phosphate and an amount of at least one disintegrant, preferably two disintegrates such as microcrystalline cellulose and starch sufficient to provide dissolution of at least about 80 % by weight of the pharmaceutical composition in about 45 minutes and suitable for oral administration to treat allergic reactions in mammals such as man are disclosed.

L'invention concerne des compositions pharmaceutiques stables contenant 8-chloro- 6,11-dihydro- 11(4-pipéridylidène)- 5H-benzo[5,6] cyclohepta [1,2-b] pirydine ("DCL") et une dose protectrice DCL d'un sel basique acceptable sur le plan pharmaceutique tel que le phosphate dibasique de calcium ainsi qu'une dose d'au moins un désintégrant, de préférence deux désintégrants tels que la cellulose microcristalline et l'amidon suffisants pour permettre la dissolution d'au moins environ 80 % en poids de la composition pharmaceutique en environ 45 mn, et adaptées à une administration par voie orale pour traiter des réactions allergiques chez des mammifères tels que l'homme.

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