C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/238
C07D 401/04 (2006.01) A61K 31/47 (2006.01) C07D 215/56 (2006.01) C07D 417/04 (2006.01) C07D 487/08 (2006.01)
Patent
CA 1314544
ABSTRACT OF THE DISCLOSURE Antibacterial .beta.-cyano-1-cyclopropyl-1,4-dihydro-4- oxo-3-quinolinecarboxylic acid derivatives of the formula Image in which Y represents a carboxyl group, a nitrile group, an ester group -COOR1 or an acid amide group -CONR2R3, X1 represents hydrogen nitro, alkyl or halogen X4 can be hydrogen or halogen, or alkyl, R4 and R5, together with the nitrogen atom to which they are bonded, form a 5- or 6-membered heterocyclic ring which can additionally contain the atoms or groups -O-, -S-, -SO-, -SO2-, Image or Image as ring members or the group Image can also represent a ring system of the structure Image which can optionally be substituted on the ring carbons by methyl and pharmaceutically usable hydrates, salts or esters thereof. These compounds have a high antibacterial activity and are therefore suitable as active compounds for human and veterinary medicine.
557311
Endermann Rainer
Grohe Klaus
Haller Ingo
Metzger Karl G.
Petersen Uwe
Aktiengesellschaft Bayer
Endermann Rainer
Fetherstonhaugh & Co.
Grohe Klaus
Haller Ingo
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