8-fluorimidazo'1,2-a!pyridine derivatives as ligands for...

Details 8-fluorimidazo'1,2-a!pyridine derivatives as ligands for... 8-fluorimidazo'1,2-a!pyridine derivatives as ligands for...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/505 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2486753

A class of 8-fluoroimidazo~1,2-a~pyridine derivatives, substituted at the 3- position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the .alpha.2 and/or .alpha.3 and/or .alpha.5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

L'invention concerne une classe de dérivés de 8-fluoroimidazoÝ1,2-.alpha.¨pyridine substitués en position 3 par un noyau hétéroaromatique à cinq ou six éléments éventuellement substitué. Ces dérivés sont des ligands sélectifs pour les récepteurs GABA<SB>A</SB> et présentent notamment une affinité élevée pour la sous-unité A2 et/ou A3 et/ou A5 correspondante. Par conséquent, ils sont utiles dans le traitement et/ou la prévention d'affections du système nerveux central, telles que l'anxiété, les convulsions et les troubles cognitifs.

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