C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/252 (2006.01) A61K 31/70 (2006.01) C07C 46/00 (2006.01) C07C 50/36 (2006.01) C07C 50/38 (2006.01)
Patent
CA 2196752
8-fluoro-anthracyclines of formula (I) having cis-stereochemistry between the groups 8-F and 9-OH, are described, such compounds present anti-tumor activity. Their preparation and pharmaceutical compositions containing them are also described.
La présente invention concerne des 8-fluoro-anthracyclines représentées par la formule générale (I) et présentant une configuration stéréochimique cis entre les groupes 8-F et 9-OH. Ces composés font preuve d'une activité antitumorale. L'invention concerne également la préparation de ces composés et des compositions pharmaceutiques les contenant.
Animati Fabio
Arcamone Federico
Giannini Guiseppe
Lombardi Paolo
Monteagudo Edith
A. Menarini Industrie Farmaceutiche Riunite S.r.l.
Bristol-Myers Squibb S.p.a.
Shapiro Cohen
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