8-heteroaryl xanthine adenosine a2b receptor antagonists

Details 8-heteroaryl xanthine adenosine a2b receptor antagonists 8-heteroaryl xanthine adenosine a2b receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 473/06 (2006.01) A61K 31/167 (2006.01) A61K 31/42 (2006.01) A61K 31/522 (2006.01) A61P 37/00 (2006.01) C07D 473/04 (2006.01) C07D 473/08 (2006.01)

Patent

CA 2443023

The present invention relates to compounds of formula (IA): the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as potent or selective A2B adenosine receptor antagonists and their uses for treating asthma, autoimmune diseases and retinal vascular diseases.

L'invention concerne des composés représentés par la formule (IA), la préparation, les formulations pharmaceutiques et l'utilisation de ces composés en médecine comme antagonistes puissants ou sélectifs du récepteur A¿28? de l'adénosine, ainsi que leur utilisation dans le traitement de l'asthme, des maladies auto-immunes et des affections vasculaires rétiniennes.

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