8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-m...

Details 8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-m... 8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-m...

C - Chemistry, Metallurgy

07

D

C07D 215/26 (2006.01)

Patent

CA 2560650

The invention relates to 8-hydroxy-5- [(1 R)-1-hydroxy-2~[[(1R)-2-(4- methoxyphenyl)-1-methyl ethyl] amino] ethyl] -2 (1 H)-quinolinone monohydrochloride of formula (I) in crystalline form, provided with suitable characteristics in order to be used for the preparation of pharrmaceutical compositions for inhalation in combination with suitable carriers or vehicles and the process for its preparation.

L'invention concerne du monohydrochlorure de 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-méthoxyphényl)-1-méthyléthyl]amino]éthyl]-2(1H)-quinolinone de formule (I) sous forme cristalline présentant des caractéristiques appropriées pour être utilisé dans la préparation de compositions pharmaceutiques à inhaler, en association avec des adjuvants ou des excipients appropriés. L'invention concerne également un procédé de préparation associé.

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