C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/48 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 215/36 (2006.01) C07D 215/60 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2262786
The present invention provides for 8-hydroxy-7-substituted quinoline compounds such as formula (IA). These compounds are useful as anti-viral agents. Specifically, these compounds have anti-viral activity against the herpes virus, cytomegalovirus (CMV). Many of these compounds are also active against other herpes viruses, such as the varicella zoster virus, the Epstein-Barr virus, the herpes simplex virus and the human herpes virus type 8 (HHV-8).
L'invention concerne des composés de 8-hydroxyquinoléine substituée en 7, représentés par la formule (IA). Ces composés sont utiles comme agents antiviraux. Ils présentent en particulier une activité antivirale contre le virus herpétique cytomégalovirus (CMV). Un grand nombre de ces composés sont également actifs contre d'autres virus herpétiques tels le virus varicelle-zona, le virus Epstein-Barr, le virus herpes simplex et le virus herpétique humain de type 8 (VHH-8).
Bezencon Olivier
Romero Arthur G.
Romines Karen R.
Strohbach Joseph W.
Thaisrivongs Suvit
Macrae & Co.
Pharmacia & Upjohn Company
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