8-hydroxyquinoline chelating agents

Details 8-hydroxyquinoline chelating agents 8-hydroxyquinoline chelating agents

C - Chemistry, Metallurgy

07

D

195/122, 260/209

C07D 215/48 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01) C07C 211/28 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07D 401/14 (2006.01) C07K 7/04 (2006.01)

Patent

CA 1336827

The present invention provides linear, cyclic and trifurcate tri- and tetramine backbone multidentate chelating agents based on the 8-hydroxyquinoline chelating unit. The chelating agents may optionally be substituted with a substrate reactive moiety and antibody-metal ion conjugates may be produced for in vivo diagnostic and therapeutic methods.

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