A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07D 215/16 (2006.01)
Patent
CA 2726537
The application relates to compositions and methods for treating hematological malignancies and proliferative diseases, disorders and conditions involving increased D-cyclin expression. In particular, the application relates to compositions and methods for treating the hematological malignancies acute myeloid leukemia (AML), lymphoma and multiple myeloma (MM) using 5-nitrogen substituted hydroxy quinolones as well as 7-bromo-5-chloro substituted hydroxy quinolones and 5-chloro substituted hydroxy quinolones.
L'invention porte sur des compositions et des procédés pour traiter des hémopathies malignes ainsi que des maladies, troubles et états prolifératifs mettant en jeu une expression accrue de la D-cycline. En particulier, l'invention porte sur des compositions et des procédés pour traiter les hémopathies malignes, notamment la leucémie myéloïde aiguë (AML), le lymphome et le myélome multiple (MM) à l'aide d'hydroxyquinolones substituées par l'azote en position 5 ainsi que d'hydroxyquinolones substituées par 7-bromo-5-chloro et d'hydroxyquinolones substituées par 5-chloro.
Batey Robert A.
Li Xiaoming
Mao Xinliang
Schimmer Aaron D.
Wood Tabitha
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Governing Council Of The University Of Toronto
University Health Network
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