C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 455/03 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 455/02 (2006.01)
Patent
CA 2166233
A compound of formula (I) Image (I) in which X represents a hydrogen or halogen atom, a C1-C3 alkyl group, a trifluoromethyl group, or a C1-C3 alkoxy group in which case two such alkoxy groups X can be present, Y represents a hydrogen or halogen atom, a C1-C3 alkyl group or a C1-C3 alkoxy group, R represents: a hydroxyl group; a methoxy group; or a group of formula NR2R3 in which R2 and R3 each independently represents a hydrogen atom, a C1-C4 alkyl group, a 2-methoxyethyl group, a 2-aminoethyl group, a 3-aminopropyl group, a 2-(dimethylamino)ethyl group, a 3-(dimethylamino)propyl group or a 2-piperid-1-ylethyl group, or alternatively R2 and R3 form, together with the nitrogen atom which they are attached, a morpholinyl or pyrrolidinyl ring or a piperazinyl ring 39 optionally substituted in the 4-position with a methyl or (1,1-dimethyl-ethoxy)carbonyl group, in the form of the free base or of a pharmaceutically acceptable addition salt thereof, processes for their preparation and their therapeutic application.
Dachary Emmanuelle
Froissant Jacques
Marabout Benoit
Sevrin Mireille
Kirby Eades Gale Baker
Sanofi-Synthelabo
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