C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/00 (2006.01) C07D 215/16 (2006.01)
Patent
CA 2589639
The present invention is directed to certain 8-phenyl-5,6,7,8- hydroquinolinecompounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
L'invention concerne certains composés de 8-phényl-5,6,7,8-hydroquinoline. Ces composés sont utiles en tant qu'antagonistes du récepteur de neurokinine-1 (NK-1). L'invention concerne également des inhibiteurs de tachykinine et en particulier une substance P. L'invention concerne encore des formulations pharmaceutiques comprenant ces composés en tant que principes actifs, et leur utilisation, ainsi que leurs formulations pour traiter certains troubles, notamment les vomissements, l'incontinence urinaire, la dépression et l'anxiété.
Bao Jianming
Devita Robert J.
Jiang Jinlong
Mills Sander G.
Merck And Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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