8-phenyl-5,6,7,8-hydroquinoline tachykinin receptor antagonists

Details 8-phenyl-5,6,7,8-hydroquinoline tachykinin receptor antagonists 8-phenyl-5,6,7,8-hydroquinoline tachykinin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 215/00 (2006.01) C07D 215/16 (2006.01)

Patent

CA 2589639

The present invention is directed to certain 8-phenyl-5,6,7,8- hydroquinolinecompounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

L'invention concerne certains composés de 8-phényl-5,6,7,8-hydroquinoline. Ces composés sont utiles en tant qu'antagonistes du récepteur de neurokinine-1 (NK-1). L'invention concerne également des inhibiteurs de tachykinine et en particulier une substance P. L'invention concerne encore des formulations pharmaceutiques comprenant ces composés en tant que principes actifs, et leur utilisation, ainsi que leurs formulations pour traiter certains troubles, notamment les vomissements, l'incontinence urinaire, la dépression et l'anxiété.

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