8-substituted b-nor-6-thiaequilenin compounds having...

Details 8-substituted b-nor-6-thiaequilenin compounds having... 8-substituted b-nor-6-thiaequilenin compounds having...

C - Chemistry, Metallurgy

07

D

C07D 333/78 (2006.01) A61K 31/38 (2006.01) C07J 73/00 (2006.01)

Patent

CA 2212204

Certain B-nor-6-thiaequilenin compounds substituted at the 3-position with hydroxy and at the 8-position with hydroxy or alkoxy of from one to four carbon atoms are selective estrogen receptor modulators and are useful in the treatment of estrogen receptor modulators and are useful in the conditions as osteoporosis, hyperlipidemia, estrogen-dependent breast cancer, uterine fibrosis, endometriosis, and restenosis.

Certaines B-nor-6-thiaéquilénines avec substitution en 3 par un hydroxy et en 8 par un hydroxy ou un alcoxy de un à quatre atomes de carbone sont des modulateurs sélectifs des récepteurs oestrogéniques et sont utiles pour le traitement de ces modulateurs; elles sont indiquées dans les affections comme l'ostéoporose, l'hyperlipidémie, le cancer du sein d'origine oestrogénique, la fibrose utérine, l'endométriose et la resténose.

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