8-substituted benzoazepines as toll-like receptor modulators

Details 8-substituted benzoazepines as toll-like receptor modulators 8-substituted benzoazepines as toll-like receptor modulators

C - Chemistry, Metallurgy

07

D

C07D 223/16 (2006.01) A61K 31/55 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2619581

Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

L'invention porte sur des compositions et méthodes de modulation de signalisation par l'intermédiaire des récepteurs Toll-like TLR7 et/ou TLR8. Lesdites compositions et méthodes s'avèrent utiles dans le traitement: de l'auto-immunité, d'allergies inflammatoires, de l'asthme, du rejet des greffes, de la réaction greffe contre hôte, des infections, de la sepsie, du cancer et de l'immunodéficience.

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