8-substituted isoquinoline derivatives and the use thereof

Details 8-substituted isoquinoline derivatives and the use thereof 8-substituted isoquinoline derivatives and the use thereof

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/501 (2006.01) A61K 31/5377 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 17/04 (2006.01) A61P 17/06 (2006.01) A61P 19/00 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 217/02 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01

Patent

CA 2738563

The present invention relates to a compound represented by the following formula (1): (see formula 1) wherein D1, A1, D2 , R1, D3 , and R2 each have the same meaning as defined in the present specification or a salt thereof. The compound represented by the formula (1) or a salt thereof has an IKK.beta. inhibiting activity and the like and is useful for the prevention and/or treatment of IKK.beta.-associated diseases or symptoms and the like.

La présente invention concerne un composé de formule (1) [où D1, A1, D2, R1, D3 et R2 sont tels que définis dans la description] ou son sel. Le composé de formule (1) ou son sel inhibe IKKß et équivalent. En conséquence, le composé ou son sel peut être utilisé en vue de la prévention et/ou du traitement d'une maladie ou d'une affection associée à IKKß, et équivalent.

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