C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/48 (2006.01) A61K 31/4375 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61K 31/538 (2006.01) A61P 3/00 (2006.01) A61P 5/50 (2006.01) A61P 9/00 (2006.01) A61P 35/02 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2754058
Provided herein are 8-substituted quinolines and related analogues as sirtuin- modulating compounds of Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
Cette invention concerne des quinoléines substituées en 8 et analogues associés utilisés comme composés modulant la sirtuine de formule structurelle (I) et leurs procédés d'utilisation. Les modulateurs de sirtuine peuvent être utilisés pour augmenter la durée de vie d'une cellule, et traiter et/ou prévenir un large éventail de maladies et de troubles, notamment les maladies et les troubles associés au vieillissement ou au stress, au diabète, à l'obésité, aux maladies neurodégénératives, aux maladies cardiovasculaires, aux troubles de la coagulation, à l'inflammation, cancer et/ou aux bouffées congestives ainsi qu'aux maladies et aux troubles bénéficiant d'un accroissement de l'activité mitochondriale. L'invention concerne également des compositions contenant un composé modulateur de sirtuine en association avec un autre agent thérapeutique.
Casaubon Rebecca L.
Vu Chi B.
Gowling Lafleur Henderson Llp
Sirtris Pharmaceuticals Inc.
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