C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/16 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2398064
A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, breast, pancreas, colon, lymphocytic and lung cancers. Consequently, 84P2A9 provides a diagnostic and/or therapeutic target for cancers, and the 84P2A9 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
L'invention concerne un nouveau gène (désigné 84P2A9) et sa protéine codée. Alors que 84P2A9 présente une expression spécifique de la prostate et du testicule dans un tissu adulte sain, il est exprimé de manière aberrante dans de multiples cancers, y compris le cancer de la prostate, du testicule, du rein, du cerveau, des os, de la peau, de l'ovaire, du sein, du pancréas, du côlon, de lymphocyte, et du poumon. Par conséquent, 84P2A9 fournit une cible diagnostique et/ou thérapeutique pour les cancers, et le gène 84P2A9 ou un fragment de celui-ci, ou sa protéine codée ou un fragment de celle-ci, peut être utilisé pour déclencher une réponse immune.
Afar Daniel E. H.
Challita-Eid Pia M.
Hubert Rene S.
Jakobovits Aya
Levin Elana
Agensys Inc.
Fetherstonhaugh & Co.
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