C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/227, 260/277
C07D 219/10 (2006.01) A61K 31/47 (2006.01) C07D 219/12 (2006.01) C07D 221/16 (2006.01) C07D 405/10 (2006.01) C07D 409/10 (2006.01) C07D 409/12 (2006.01)
Patent
CA 1292744
ABSTRACT There are disclosed compounds having the formula Image wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR2 where R2 is loweralkyl, or NR3R4 where R3 and R4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C=O or CR5OH where R5 is hydrogen or loweralkyl; Z is CH2 or C=CR6R7 where R6 and R7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR5=CH where CR5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.
493743
Pierrat Frank A.
Shutske Gregory M.
Aventis Pharmaceuticals Inc.
Bereskin & Parr
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